Analyzing Liver Tissue Responses To Local Hemostatic Agents

Objective – Our study aimed at evaluating changes in liver tissues after simulated injury and use of novel hemostatic agents (containing tranexamic acid) the course vivo experiment. Material Methods The following were studies: TachoComb collagen plate (Group 1); samples local based on sodium carboxymethyl cellulose (CMC), Na-CMC 2); + acid 3). We performed 30 rabbits with laceration via laparoscopy, stopping bleeding by means above-mentioned methods. Then, tissue micrographs, we measuring capsule thickness (μm), sizes hepatocytes their nuclei (px), number binuclear hepatocytes. also calculating nuclear-cytoplasmic ratio (NCR) hepatocytes, as well identifying qualitative quantitative composition tested samples. Results In group, width was 3.2-fold 3.6-fold this parameter from Groups 2 3. Indirectly, finding implied more severe inflammatory regenerative processes limiting area, confirmed statistically significant differences cellular surrounding (fibroblastic cells predominated 3, there fewer them Group 1). highest cell index (CI) value detected Conclusion A boundary zone separating materials parenchyma observed due to connective growth part response.